Genetic Toxicology
Genetic toxicology deals with the study of effects of different physical, chemical and biological substances on genetic material. It identifies the possible reasons for occurrence of birth defects, heritable mutations and carcinogenesis.
Mutations are caused due to genetic damage. The property of the chemical agent which causes the genetic damage is studied under genotoxicity. Mutations are the main cause for carcinogenesis.
Mutagenesis occurs spontaneously in the nature which results in the change in genetic information of an organism in a stable manner. It may also occur due to mutagens.
Genotoxic chemotherapy induces DNA damage in the cancer cells thus leading to their death. It is done by using one or more Genotoxic drugs. Damage done to a cancer is passed on to descendent cancer cells as proliferation continues. Apoptosis is induced under severe conditions
- Chromosome Aberration
- Gene Mutation
- In Vitro Toxicology
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